4 Groundbreaking Studies for Alzheimer's Prevention

There have been significant strides made in recent years towards the prevention of Alzheimer's disease.

Several groundbreaking studies have emerged, highlighting the importance of lifestyle interventions with diet, sleep, exercise, and the pillars of brain health in reducing the risk of cognitive decline and dementia.

Groundbreaking Studies for Alzheimer's Prevention:

FINGERS Trial 2017: The Karolinska Institute in Sweden presented the latest in prevention strategies for Alzheimer’s, emphasizing the five “FINGERS” of healthy diet, exercise, cognitive stimulation, social interaction, and cardiovascular health. Results were promising, showing that multidomain intervention could benefit cognitive functioning in at-risk elderly people.1

Link to Sleep 2019: With an overview of recent studies on sleep, observed with both mice and humans, the understanding of the bidirectional relationship between sleep and Alzheimer's is becoming more apparent. By studying the role of amyloid, tau, and other factors, it was found that Alzheimer's/Dementia pathology is linked to irregular or poor quality of sleep.2   

EXERT Trial 2022: Wake Forest University released the results of an exercise study, showing that either aerobic or stretching/balance exercises for 120-150 minutes per week appeared to stall the progression of cognitive decline in people at-risk of Alzheimer’s disease over a 12-month period.3   

MIND Diet 2022: A 3-month randomized control study on middle-aged obese women showed the results of adhering to the MIND diet and how it may improve cognitive performance.4 This new evidence continues to build support for the MIND diet studies that have been done over the last decade. Expect to see more news on this from Rush University Medical Center in the coming months of 2023.

The MIND diet, is a relatively new and groundbreaking approach to nutrition, and has been gaining attention for its proven impact on brain health. Combining elements of the Mediterranean diet and the DASH (Dietary Approaches to Stop Hypertension) diet, the MIND diet is designed to specifically target cognitive function and reduce the risk of neurodegenerative diseases, such as Alzheimer's. 

It’s always best to get these important nutrients from the foods we eat, but the reality is that most of us do not follow the MIND diet consistently. RELEVATE is a nutritional supplement that helps to fill in gaps when our diet falls short. RELEVATE has 17 crucial nutrients from the MIND diet which are neuroprotective, bioavailable, and include the forms/dosages your brain needs. 

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1. Rosenberg, A., (2018), Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial. Alzheimer's & Dementia, 14: 263-270.

2. Wang, C., Holtzman, D.M (2020). Bidirectional relationship between sleep and Alzheimer’s disease: role of amyloid, tau, and other factors. Neuropsychopharmacol. 45, 104–120 https://doi.org/10.1038/s41386-019-0478-5

3. Baker L. Topline Results of EXERT: Can Exercise Slow Cognitive Decline in MCI? [Conference abstract]. AAIC 2022, July 31-August 4 2022.

4. Arjmand, G., Abbas-Zadeh, M. & Eftekhari, M.H. Effect of MIND diet intervention on cognitive performance and brain structure in healthy obese women: a randomized controlled trial. Sci Rep 12, 2871 (2022). https://doi.org/10.1038/s41598-021-04258-9
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