Powerful Polyphenols: Supporting a Healthier Brain

April 23, 2025

As we age, preserving brain health is more than just a good idea — it becomes essential.   We might already prioritize exercise, nutrition, and sleep, but are we giving our brains the proper nutrients to thrive for years down the line?  With growing scientific validation, polyphenols are emerging as a powerful group of plant compounds with the ability to help the brain stay sharp, resilient, and balanced.    

What Are Polyphenols?   

Polyphenols are a diverse group of nutrients naturally found in plant-based foods.  They offer powerful antioxidant and anti-inflammatory effects, which protect the body from cellular damage and potential chronic illnesses. 

There are four main categories of polyphenols:1 

Flavonoids are the largest and most well-known group of polyphenols.  Some specific examples include quercetin, catechins, anthocyanins, and kaempferol.  They are found in fruits, vegetables, tea, and even dark chocolate!  

Phenolic acids make up the second-largest group of polyphenols.  These compounds are found in coffee, berries, and whole grains.  

Stilbenes are less common, but resveratrol (found in red wine and grapes) is a well-known and significant example.  

Lignans are found in seeds (specifically flaxseeds), whole grains, legumes, and vegetables.   

Polyphenols comprise a vast array of plant compounds, each offering unique benefits for brain health.  While they vary in structure and food sources, what unites these nutrients is their impressive potential to support long-term cognitive health, especially as we age.   

Deficient Intake of Polyphenols  

Most modern diets fall short when it comes to polyphenol intake.  Highly processed foods, limited fruit and vegetable consumption, and a lack of dietary variety contribute to this nutritional gap.  As a result, many people miss out on the protective effects these plant compounds offer.  According to epidemiological research and the Dietary Guidelines for Americans, most people in the U.S. consume 50–85% fewer whole plant foods than recommended.2  That means they’re likely falling just as short on polyphenols.  Does this sound familiar for you or someone in your family? 

A deficiency in polyphenols may raise the risk of several chronic diseases, including cardiovascular issues and neurodegenerative disorders.3   When the body lacks sufficient antioxidant support, oxidative stress and chronic inflammation can take a toll — damaging cells and accelerating the aging process in both body and brain.4   

Research even points out that polyphenol-rich diets are associated with better cognitive performance and a lower risk of neurodegenerative diseases like Alzheimer’s and Parkinson’s.5  And the benefits don’t stop at the brain — a recent research review linked low intake of polyphenols with an increased risk of chronic diseases such as cardiovascular disease, type 2 diabetes, and all-cause mortality.6  These findings indicate that a diet rich in polyphenols is crucial to preserving memory, focus, and mental clarity.   

Understanding How Polyphenols Benefit Your Brain Health  

Polyphenols’ antioxidant and anti-inflammatory effects are at the core of their brain-boosting power, helping to reduce damage caused in-turn by oxidative stress and chronic inflammation — two major drivers of cognitive decline and neurodegenerative conditions.   

Overall, polyphenols can benefit your brain health by:   

  • Reducing brain inflammation: Chronic inflammation is a hallmark of many neurological conditions.  Polyphenols help calm inflammatory pathways and bring the immune system into balance in the brain, creating a healthier environment for cognitive function.7   

  • Supporting neuroplasticity: Certain polyphenols can promote the growth and strengthening of neural connections — a process called neuroplasticity — which is key to learning, memory, and long-term brain resilience.8  

  • Improving blood flow to the brain: Polyphenols support healthy blood vessel function and circulation, meaning more oxygen and nutrients can reach your brain.9  

  • Reducing accumulation of amyloid-beta plaques: These sticky protein clumps are associated with Alzheimer’s disease.  Some polyphenols may even reduce their buildup or support the brain’s natural clearing processes.10 

  • Protecting against brain cell death: Polyphenols help defend neurons from premature damage or death by combating oxidative stress and stabilizing cellular processes.7  

  • Generally, lowering the risk of cognitive decline and neurodegenerative diseases: Regular intake of polyphenol-rich foods is linked to better cognitive performance and a reduced risk of conditions like Alzheimer’s and Parkinson’s disease.7  

Polyphenol Food Sources:  Where to Find Them 

Diet and brain health go hand in hand, especially when polyphenols are abundant in your food choices.  The best part?  A wide range of foods contain polyphenols, making it easier than you might think to weave them into your everyday meals.  Here are some of the top brain boosting foods rich in polyphenols: 

  • Fruits: Berries (especially blueberries, strawberries, and blackberries), apples, and cherries are all rich in polyphenols like anthocyanins and flavonols. 

  • Leafy Greens: Vegetables such as spinach, kale, and broccoli contain polyphenols, particularly kaempferol, and other essential nutrients that support overall health. 

  • Other Vegetables: Onions and capers are particularly high in quercetin, a common flavonoid linked to better cognitive function. 

  • Nuts and Seeds: Walnuts, almonds, and chia seeds provide polyphenols and healthy fats that fuel brain function. 

  • Beverages: Coffee, green tea, and even red wine are notable sources of polyphenols, specifically catechins. 

Extra Virgin Olive Oil: A Special Class of Polyphenols 

Extra virgin olive oil (EVOO) stands out not just as a healthy fat but as one of the best foods high in polyphenols with neuroprotective potential.  EVOO contains oleocanthal hydroxytyrosol, oleuropein, and tyrosol — four potent compounds scientific research is indicating may provide immense support to brain function and healthy aging.  Here’s how:     

  • Oleocanthal is EVOO’s anti-inflammatory hero polyphenol, shown to have even stronger effects against inflammation than the drug ibuprofen.  On top of that, oleocanthal is resistant to heating when cooking, giving it more flexibility for brain healthy eating.11

  • Hydroxytyrosol offers potent antioxidant activity, helping to reduce oxidative stress in brain cells.12, 13 

  • Oleuropein may help reduce neuroinflammation and prevent the buildup of harmful proteins linked to cognitive decline.13   

  • Tyrosol supports cellular function and may assist in brain cell signaling.12, 13 

Nutrient-rich foods often lose potency through cooking, but that’s not the case for extra virgin olive oil.  EVOO retains much of its polyphenol content (not just oleocanthal) when consumed raw or lightly cooked — such as drizzled over salads or vegetables or even taken by the spoonful.  In fact, people who ingest more than one tablespoon of olive oil per day have a 28% lower risk of dying from dementia compared to those who rarely consume it.14   

Follow the Mediterranean and MIND diets for one of the simplest ways to enjoy brain enhancing foods.  Both diets emphasize whole, minimally processed foods, naturally filled with these brain-supportive compounds.  A study on the Green Mediterranean diet (a plant-heavy version of the Mediterranean diet) showed improved blood sugar control after 18 months and signs of healthier brain aging.15 

Other Benefits of Polyphenols:  Beyond the Brain 

Polyphenols’ benefits go far beyond cognitive function — they play a significant role in whole-body health!  These compounds are mighty multitaskers that support nearly every system in the body, such as: 

  • Heart health: Polyphenols help improve blood vessel function and reduce peripheral inflammation, reducing cardiovascular disease risk.16 

  • Cancer protection: Certain polyphenols may help block cancer cell growth and promote the body’s natural defense mechanisms against it.17 

  • Blood sugar regulation: Polyphenols can improve insulin sensitivity and reduce the risk of developing type 2 diabetes.18 

  • Gut health: Polyphenols help maintain a healthy balance of gut bacteria, contributing to better digestion — and even supporting brain health through the gut-brain connection.19 

  • Skin and hair support: Their antioxidant properties contribute to a youthful glow by helping protect skin cells from damage and even may prevent hair loss.20 

Polyphenols’ natural antioxidant and anti-inflammatory properties offer a nearly endless supply of benefits to the entire human body — both inside and out.  

Incorporating more polyphenol-rich foods into your diet can help protect your brain from age-related decline, enhance cognitive function, and support overall well-being.  Given their far-reaching benefits, polyphenols should be integral to a balanced, healthy diet.  However, if you struggle to get enough polyphenols from food alone, a polyphenols supplement can effectively bridge the gap and help ensure optimal brain health. 

Brain health supplement, RELEVATE, contains several polyphenol compounds, including quercetin, catechins, anthocyanins, kaempferol, and myricetin, alongside other comprehensive nutrients to sharpen and protect your brain.  Ready to maximize the power of polyphenols?  This month, enjoy our limited-time offer where when you buy one bottle of RELEVATE, get the second for 50% OFF, plus a polyphenol-rich limited release Ethiopian Coffee from our partners at Purity, and a NeuroReserve Branded Mug to enjoy it.  Click here to order and learn more.

References

1. Pandey, K. B. & Rizvi, S. I. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev 2, 270–8 (2009). 

2. Guenther, P. M., Dodd, K. W., Reedy, J. & Krebs-Smith, S. M. Most Americans eat much less than recommended amounts of fruits and vegetables. J Am Diet Assoc 106, 1371–1379 (2006). 

3. Cory, H., Passarelli, S., Szeto, J., Tamez, M. & Mattei, J. The Role of Polyphenols in Human Health and Food Systems: A Mini-Review. Front Nutr 5, (2018). 

4. Liguori, I. et al. Oxidative stress, aging, and diseases. Clin Interv Aging 13, 757–772 (2018). 

5. Vauzour, D., Rodriguez-Mateos, A., Corona, G., Oruna-Concha, M. J. & Spencer, J. P. E. Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action. Nutrients 2, 1106–1131 (2010). 

6. Del Bo’, C. et al. Systematic Review on Polyphenol Intake and Health Outcomes: Is there Sufficient Evidence to Define a Health-Promoting Polyphenol-Rich Dietary Pattern? Nutrients 11, 1355 (2019). 

7. Vauzour, D. Dietary Polyphenols as Modulators of Brain Functions: Biological Actions and Molecular Mechanisms Underpinning Their Beneficial Effects. Oxid Med Cell Longev 2012, 1–16 (2012). 

8. Cichon, N., Saluk-Bijak, J., Gorniak, L., Przyslo, L. & Bijak, M. Flavonoids as a Natural Enhancer of Neuroplasticity-An Overview of the Mechanism of Neurorestorative Action. Antioxidants (Basel) 9, (2020). 

9. Ammar, A. et al. Effects of Polyphenol-Rich Interventions on Cognition and Brain Health in Healthy Young and Middle-Aged Adults: Systematic Review and Meta-Analysis. J Clin Med 9, 1598 (2020). 

10. Freyssin, A., Page, G., Fauconneau, B. & Rioux Bilan, A. Natural polyphenols effects on protein aggregates in Alzheimer’s and Parkinson’s prion-like diseases. Neural Regen Res 13, 955 (2018). 

11. Buga, A.-M., Oancea, C. N., Gonçalves, M., Vale, N. & Silva, P. Neuroprotective Effects of Olive Oil: A Comprehensive Review of Antioxidant Properties. Antioxidants 2024, Vol. 13, Page 762 13, 762 (2024). 

12. Boronat, A., Serreli, G., Rodríguez-Morató, J., Deiana, M. & de la Torre, R. Olive Oil Phenolic Compounds’ Activity against Age-Associated Cognitive Decline: Clinical and Experimental Evidence. Antioxidants (Basel) 12, (2023). 

13. Micheli, L. et al. Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota. Nutrients 15, (2023). 

14. Tessier, A.-J. et al. Consumption of Olive Oil and Diet Quality and Risk of Dementia-Related Death. JAMA Netw Open 7, e2410021 (2024). 

15. Pachter, D. et al. Glycemic control contributes to the neuroprotective effects of Mediterranean and green-Mediterranean diets on brain age: the DIRECT PLUS brain-magnetic resonance imaging randomized controlled trial. Am J Clin Nutr 120, 1029–1036 (2024). 

16. Iqbal, I. et al. Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review. Molecules 28, (2023). 

17. Bhosale, P. B. et al. Functions of polyphenols and its anticancer properties in biomedical research: a narrative review. Transl Cancer Res 9, 7619–7631 (2020). 

18. Aryaeian, N., Sedehi, S. K. & Arablou, T. Polyphenols and their effects on diabetes management: A review. Med J Islam Repub Iran 31, 134 (2017). 

19. Filosa, S., Di Meo, F. & Crispi, S. Polyphenols-gut microbiota interplay and brain neuromodulation. Neural Regen Res 13, 2055 (2018). 

20. Sun, M. et al. Effects of Natural Polyphenols on Skin and Hair Health: A Review. Molecules 27, (2022). 

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