REO3 High Potency Omega-3 with SPMs

Omega-3 fats come in different forms, and there are three main types: triglyceride, ethyl ester, and phospholipid. Triglyceride and ethyl ester omega-3s are “standard” forms that are commonplace among supplements. These forms are taken from the body of fish, and when they are concentrated, the process makes them less efficient to absorb (particularly for ethyl ester forms). Phospholipid omega-3s are in a structural form that is similar to the molecules in human cell walls. This significantly increases their absorption compared triglyceride and ethyl ester omega-3s. Also, phospholipid omega-3s dissolve better in water, making them less dependent on having fatty foods for them to absorb. These two absorption advantages make phospholipid omega-3s a strong choice to boost the transfer of the omega-3s from the gut, to the blood, and therefore to the rest of your organs that need them.

REO3 uses a unique phospholipid omega-3, derived not from the body but instead from the roe (caviar/egg) of fish, resulting in a DHA-enriched omega-3 that delivers twice as much omega-3 (DHA+EPA) into the bloodstream as a standard omega-3 at the same dose.* Even more, the specific phospholipid structures of REO3 omega-3s are called phosphatidylcholine (PC) and lysophosphatidylcholine (LPC). These more readily cross from bloodstream into the brain.

* Cook, C. M. et al. Prostaglandins Leukot. Essent. Fatty Acids 111, 17–24 (2016).

Specialized pro-resolving mediators (SPMs) are molecules that act as your body’s natural "stop signs" for inflammation. SPMs enable a process called inflammation resolution, which is when the body brings an inflammatory event (e.g. stress, injury, infection) to its proper conclusion. The resolution process helps prevent inflammation from lingering as low-grade (or chronic) inflammation. Another way of putting it: After inflammation “switches on” and the immune system goes on the attack, SPMs then guide the process of “switching it off.” SPMs are the body’s natural way of calming down the inflammatory response, rather than other methods that artificially block or suppress inflammation.

SPMs:

• Stop the fire: They signal your immune system to turn down active inflammation.
• Clear the debris: They prompt immune cells to clean up dead cells and debris.
• Repair the tissue: They speed up the local healing process after injury or illness.

While SPMs are produced naturally by the body, the aging process may reduce or change the effectiveness of SPMs.

If you’re like most adults, your diet is probably well under the recommended consumption levels for omega-3s. More than 90% of Americans do not consume the recommended amount of seafood, which is the major source of omega-3 fatty acids DHA and EPA. The average American only consumes about 100 mg of omega-3 per day, while the American Heart Association (AHA) recommends at least 2 servings of fatty fish per week, which includes fish like salmon, mackerel, anchovies, sardines, and herring.* Depending on the type of fish eaten, this translates into a recommendation of about 500 mg per day of DHA and EPA (the combined total of both). DHA and EPA are the most physiologically relevant omega-3 fatty acids and most strongly linked to human health benefits. The recommended amount is even more for certain risk factors and conditions.

Thus, if you’re not eating at least 2 servings of fatty fish per week, then you are very likely falling short of minimum requirements of a healthy diet for brain, heart, eye, skin, and joint health, just to name a few.

Also, as we age, everyday inflammatory discomfort may increase, while at the same time our ability to resolve (or terminate) inflammation may decrease due to reductions in SPM production or efficiency. (Read more about SPMs here and in this Q&A.)

REO3 can help you fill both omega-3 and SPM gaps – supporting whole-body healthy aging.

References:
* Papanikolaou, Y., Brooks, J., Reider, C. & Fulgoni, V. L. Nutr. J. 13, 31 (2014). Kris-Etherton PM, Harris WS, Appel LJ. Circulation. 106, 2747–2757 (2002).

Inflammaging is a combination of the words "inflammation" and "aging.” It refers to a state of chronic, low-grade, system-wide inflammation that naturally develops in our bodies as we get older, even if we are not sick. Think of it like a smoldering fire inside your tissues. It doesn't cause a raging emergency, but over time, that constant heat and smoke quietly damage healthy organs, joints, and blood vessels. This invisible wear-and-tear is considered by many to be a driving force behind age-related cardiovascular conditions, cognitive decline, and joint stiffness and aching.

REO3 can help because it provides two critical things the body needs to manage inflammaging. First, it provides active SPMs to “cool the burn” and resolve the inflammation. Second, it provides concentrated omega-3s that help maintain inflammatory balance, as well as being the building blocks to help repair and strengthen damaged cells.

The suggested use for REO3 is three (3) softgels daily. Though, there’s no such thing as a “standard” person. Every person is different. A person might have a diet that is very low in fatty fish and other sources of omega-3; in this case, the person may benefit from more REO3 softgels each day. Another person may have a diet that is high in fatty fish, even exceeding the recommendations of at least 2 meals with fatty fish per week (see the “Why should I take REO3?” in this Q&A for more on omega-3 recommendations). In that case, such a person may benefit with fewer REO3 softgels each day. We encourage you to establish a regular daily serving of REO3 based on our suggested use, then assess if you’re feeling benefits, and then adjust with more or less if it feels right for you.

As mentioned, every person is different, but you’ll likely get the best results from REO3 when you take it consistently as part of an overall healthy lifestyle and diet. You can take REO3 softgels with or without food. As with most nutritional supplements, taking it with food is preferable.

The time of day you take REO3 is up to you. We recommend finding a time when you can take it regularly and stick with it. You’ll notice the greatest benefits when you take it consistently.

Yes, REO3 is easy to take. The softgel is designed to be smaller than most omega-3 supplements, and its shape is a gentle and compact oval. Both of these factors make REO3 softgels easier to swallow.

And because it’s in a phospholipid form, you won’t experience the annoying (and embarrassing) fishy burps or aftertaste that come from other omega-3s.

REO3 supports your body naturally, and everyone’s experience is unique. You should notice changes over a few weeks, driven by the combined benefits of phospholipid omega-3s and SPMs for natural inflammatory resolution.

The next section of this Q&A (“What do clinical studies say?”) summarizes the results of controlled clinical trials involving REO3, omega-3s, and SPMs, along with the body systems they help support. When using REO3 in everyday, real-world settings, individual experiences will vary; however, here are a few supportive benefits you may notice by the first 8-12 weeks:

• Improved joint comfort: Your joints may feel looser and move more smoothly in the morning, or on a day-to-day basis.
• Improved mental clarity: You may feel sharper, more focused, or notice less “brain fog.”
• Faster recovery: You may “bounce back” more quickly and more comfortably from workouts, soreness, minor injuries, or intense physical activity.
• Better energy: You might notice improvements or greater consistency in your energy level throughout the day.
• Resilience: You may feel better able to adapt to daily stresses, challenges, and wear-and-tear, experiencing an overall greater sense of vitality.
• Vision comfort: You may notice more comfort and less fatigue after long days, as well as less occasional dryness or irritation.
• Skin moisture: Your skin may feel better hydrated, softer, or smoother.

At the cellular level, the intake of phospholipid omega-3s and SPMs will likely increase your omega-3 index (i.e. incorporation of omega-3s into red blood cells), increase blood levels of direct precursors to SPMs (18-HEPE, 17-HDHA, 14-HDHA), and promote favorable shifts in inflammatory blood markers.

An extensive and growing body of clinical research exists for REO3, omega-3s, and SPMs. Some of these clinical studies are described below.

REO3’s core nutrient is an omega-3/SPM formulation derived from herring roe oil. Clinical studies with this specific formulation have shown:

• Approximately two times faster absorption and correspondingly two times greater concentration of DHA+EPA in blood compared to standard fish oil.(*1)
• Increase in omega-3 index, a measure of omega-3 uptake into cells and tissues from the blood. Healthy adults experienced a 70% increase in omega-3 index after two weeks of supplementation.(*2)
• Favorable change in blood markers of cardiovascular health, including reduction in triglycerides and increase in “healthy” HDL cholesterol.(*2)
• Favorable changes in certain molecular markers of skin defense and repair (CCL), skin inflammatory response (IL-23), and skin immune activity (CD38) after a half-year of use.(*3, *4)
• Reduction in three different measures of systemic inflammation after a half-year of use in people with mild to moderate skin inflammatory condition.(*5)

Omega-3 fatty acids are among the most extensively researched nutrients in human health. Hundreds of clinical studies have investigated their effects on the brain, eyes, skin, cardiovascular health, and healthy aging.(*6) Below is a sample of clinical research demonstrating benefits of omega-3 supplementation, including phospholipid-bound omega-3s (like those in REO3), illustrating the physiological roles for DHA and EPA in supporting human health.

• Improvements in measures of memory and learning.(*7)
• Faster cognitive performance, involving working memory and reaction time.(*8)
• Healthy brain aging, indicated by maintenance of cognitive and executive function.(*9)
• Favorable changes in working memory and information processing rate.(*10)
• Reduced triglyceride levels, supporting cardiovascular health.(*11)
• Promotion of healthy blood vessel function and circulation, supporting normal cardiovascular performance.(*12, *13)
• Support of eye health through maintenance of retinal structure and visual performance.(*14)
• Improvement in skin hydration, elasticity, and reduced water loss.(*15)
• Protection of skin from UV radiation injury.(*16, *17)

Specialized pro-resolving mediators (SPMs) are an area of growing clinical research, and supplementation studies are reporting promising effects on measures of resilience and healthy aging.(*18) A sample of these is described below.

• Increases in SPM concentrations in blood after supplementation, and changes in immune cell responses toward a more protective state.(*19)
• Reduction in joint discomfort and improvement in quality of life in adults after 4 weeks, and after 12 weeks.(*20, *21)
• Reduced fatigue, and improvement in the ratio between pro-inflammatory and pro-resolution molecules in blood.(*22)

References:
*1. Cook, C. M. et al. Prostaglandins Leukot. Essent. Fatty Acids 111, 17–24 (2016).
*2. Bjørndal, B. et al. Lipids Health Dis. 13, 82- (2014).
*3. Tveit, K. S. et al. Acta Derm. Venereol. 100, 5762 (2020).
*4. Petrovic, A. et al. Front. Immunol. 14, 1128986 (2023).
*5. Ringheim-Bakka, T. A., Gammelsaeter, R. & Tveit, K. S. Front. Med. (Lausanne). 13, 1861341 (2026).
*6. Patted, P. G., Masareddy, R. S., Patil, A. S., Kanabargi, R. R. & Bhat, C. T. Future J. Pharm. Sci. 2024 10:1 10, 94- (2024).
*7. Yurko-Mauro, K. et al. Alz. & Dement. 6, 456–464 (2010).
*8. Stonehouse, W. et al. Am. J. Clin. Nutr. 97, 1134–1143 (2013).
*9. Witte, A. V. et al. Cerebral Cortex 24, 3059–3068 (2014).
*10. Konagai, C. et al. Clin. Interv. Aging 8, 1247–1257 (2013).
*11. Skulas-Ray, A. C. et al. Circulation 140, E673–E691 (2019).
*12. Wang, Q. et al. Atheroscler. 221, 536–543 (2012).
*13. Mozaffarian, D. & Wu, J. H. Y. J. Am. Coll. Cardiol. 58, 2047–2067 (2011).
*14. SanGiovanni, J. P. et al. of Ophthalmolog. 126, 1274–1279 (2008).
*15. Handeland, K., Wakeman, M. & Burri, L. J. Cosmet. Dermatol. 23, 4285–4294 (2024).
*16. Pilkington, S. M., Watson, R. E. B., Nicolaou, A. & Rhodes, L. E. Exp. Dermatol. 20, 537–543 (2011).
*17. Pilkington, S. M. et al. Am. J. Of Clin. Nutr. 97, 646–652 (2013).
*18. de Souza, L. C., Moris, J. M., Gordon, P. M., Heileson, J. L. & Funderburk, L. L. K. Nutrients 2025, Vol. 17, Page 2014 17, 2014 (2025).
*19. Souza, P. R. et al. Circ. Res. 126, 75–90 (2020).
*20. Möller, I. et al. J. Transl. Med. 21, 423- (2023).
*21. Callan, N., Hanes, D. & Bradley, R. J. Transl. Med. 18, 401- (2020).
*22. Gracia Aznar, A. et al. Biomedicines 2024, Vol. 12, Page 2221 12, 2221 (2024).

REO3 is a dietary supplement that contains omega-3 fatty acids derived from fish (herring roe/caviar oil). Because REO3 contains a fish-derived ingredient, people who are allergic to fish should not take this product or should first discuss this with their healthcare professional.

In general, most people tolerate dietary supplements that contain omega-3 fatty acids well. The most common side effects are mild and may include digestive discomfort, fishy burps, bloating, nausea, or loose stools. These effects are often temporary and can be minimized by taking omega-3 supplements with food. In addition, many people tolerate phospholipid-bound omega-3s (the type used in REO3) well, particularly when taken with food.

As with any new nutritional regimen or dietary supplement, consult with your healthcare practitioner before using this product. If you are pregnant or breastfeeding, taking any medications, or have any medical condition consult a healthcare professional before using this or any other dietary supplement.

In general, omega-3 fatty acids have excellent tolerability and safety. There is no official “upper limit” of omega-3 consumption that’s been established by the FDA or other governmental authority. However, the FDA has indicated that omega-3 dietary supplements providing up to 5000 mg per day of DHA+EPA are safe when used as recommended. Similarly, the European Food Safety Authority (EFSA) indicates that long-term use of omega-3 dietary supplements up to 5000 mg (DHA+EPA) per day appears to be safe. (Just for comparison, REO3 contains 600 mg DHA+EPA per daily suggested serving.)

REO3 combines three key advances in omega-3 science into a single product that ordinary omega-3s cannot match.

• Premium and Concentrated Origin: REO3 uses arctic herring roe (caviar/egg) oil as its core material. Conventional omega-3 supplements use oil from the body of fish, not fish roe. The result is that REO3 provides a unique DHA-enriched composition well-suited for brain health, eye health, and production of a wider range of SPMs.
• Active Inflammatory Resolution: REO3 includes abundant and quantifiable levels of specialized pro-resolving mediators (SPMs) and their direct building blocks (PRMs), adding a new way to naturally support healthy resolution of inflammation. Instead of artificially suppressing or blocking inflammation like typical approaches, REO3 helps to naturally calm down inflammation. That’s important, since chronic, low-grade inflammation is one of the biggest hallmarks of aging.
• Targeted Phospholipid Delivery: If you zoom-in on REO3 omega-3 molecules, you’ll see they look much different than conventional omega-3s. REO3 uses omega-3s in phospholipid form, unlike triglyceride or ethyl ester forms of conventional omega-3s. The result is that REO3 dissolves more rapidly, absorbs faster, raises blood levels of omega-3’s more, and gets to the places where your body needs it sooner. In fact, it’s already in the structural form to be directly incorporated into cell membranes, bypassing intermediate steps that conventional omega-3s require.

Three breakthroughs. One remarkable product. That’s the REO3 difference.

Transform the way you age with REO3.